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Does Metformin Interact With Cephalexin, Levothyroxine And Quetiapine?

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Posted on Fri, 20 Nov 2015
Question: I am reviewing drug interactions with a new medication. I found that the new medication has a "moderate" drug interaction with two of my existing meds. Should I challenge the prescribing physician? I am also puzzled as to why the pharmacy did not catch it.
doctor
Answered by Dr. Michelle Gibson James (38 minutes later)
Brief Answer:
should speak to both doctor and pharmacist

Detailed Answer:
HI, thanks for using healthcare magic

The names of the medications have not been mentioned but if you and your husband noted interactions when the medications were reviewed online then you should speak to your doctor and pharmacist.


As mentioned, if different pharmacies are used, the pharmacist may not consider interactions since they may not know all of the meds used.

With some possible interactions, the doctor is advised to monitor for possible problems and to discontinue if they occur, this means that , depending on nature of the interaction, your doctor may monitor for a problem that may or may not occur.

This can be clarified when you speak to your doctor.
If the risk of interaction is severe or unavoidable , then mixing the particular meds is not advised.

I hope this helps, feel free to ask any other questions
Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Follow up: Dr. Michelle Gibson James (14 minutes later)
I should have mentioned that I take quitiapine, lyvothyroxin and cephalexin, all of which have a "moderate" drug interaction with metformin. Is there enough concern to really push the issue?
doctor
Answered by Dr. Michelle Gibson James (39 minutes later)
Brief Answer:
main effect is on blood sugar control

Detailed Answer:
HI

The main possible effects are with blood sugar control which can be monitored with a glucometer if you have one available to you.

The quetiapine can potentially increase blood sugars , this may or may not occur but can be checked.

The cephalexin can potentially decrease blood sugars in some persons, this possible interaction may not occur. Most antibiotics are only prescribed for a short period of time so the interaction is not long term.
In addition since the quetiapine can potentially increase blood sugars and the cephalexin decrease them, there may be no over all change

The thyroid replacement medication, levothyroxine can also potentially cause elevated blood sugars.
Again this may not be significant but you can monitor for any blood sugar changes

At this point, you would mainly monitor your blood sugar, it is possible that little or no effect may occur.
If there is a significant decrease or increase in blood sugar then you can speak to your doctor about possibly altering the metformin.

Summary: (1) main effect in on blood sugar
(2)blood sugars can be monitored by home glucometer if one is available
(3) if note any significant changes then may need a change in diabetic med

Please feel free to ask any other questions
Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Michelle Gibson James

General & Family Physician

Practicing since :2001

Answered : 16808 Questions

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Does Metformin Interact With Cephalexin, Levothyroxine And Quetiapine?

Brief Answer: should speak to both doctor and pharmacist Detailed Answer: HI, thanks for using healthcare magic The names of the medications have not been mentioned but if you and your husband noted interactions when the medications were reviewed online then you should speak to your doctor and pharmacist. As mentioned, if different pharmacies are used, the pharmacist may not consider interactions since they may not know all of the meds used. With some possible interactions, the doctor is advised to monitor for possible problems and to discontinue if they occur, this means that , depending on nature of the interaction, your doctor may monitor for a problem that may or may not occur. This can be clarified when you speak to your doctor. If the risk of interaction is severe or unavoidable , then mixing the particular meds is not advised. I hope this helps, feel free to ask any other questions