Yes. I already have Nu ropy In my legs but my left leg has always had pains....for years..because of three deie points in my back....was told about Surgery...but did not think it was a good idea...So Now have Toes in my leg turning black with the night-time pain when I lay down Cramps...went to the Emergency room Dated: 9/12/2015 11:30am and was told I have PVD..and also seen my Primary Doctors and there I feel lost I can't sleep, without taking pain pills...only to wake-up with more pain and cramping pain and darkening of the lower leg and toes.