Get your health question answered instantly from our pool of 18000+ doctors from over 80 specialties

134 Doctors Online
Doctor Image
Dr. Andrew Rynne

Family Physician

Exp 50 years

I will be looking into your question and guiding you through the process. Please write your question below.

What is peripheral tolerance?

If you could describe in the most simplest terms possible
Wed, 9 Dec 2009
Report Abuse
  User's Response
's  Response

Hi.... Peripheral tolerance refers to the tolerance on the functions of the T cell and B cell. T cell and B cell are the immunity cells in the human body.   They deliver this funtion by different mechanism.  It is activated by the presence of receptors on the cells usually refered to as MHC.  The target cells for the MHC is the antigen (anything that is an not part of the body). There are instances when the MHC reacts angainst the own body resulting in the develpment of autoimmunity state or disease. The mechanism where in the develpopment of such autoimnunity is prevented is refered to as development of tolerance. It can happen either at the central level i.e at the stage of the production or at the peripheral level i.e at the stage of its release.


Disclaimer: These answers are for your information only and not intended to replace your relationship with your treating physician.
This is a short, free answer. For a more detailed, immediate answer, try our premium service [Sample answer]
Share on

Related questions you may be interested in

doctor1 MD

Hi. My name is a Patsy. I have been going thru Sm Cell Ductal Breast Cancer/Pos on FISH Test, not genetic. Stage 1. I Have been going thru treatment since Aug 2010. This month they took me off my letrozole because I m not tolerating it very well. I also have Occlusive Pheripherial Arterial Disease due to survice in the Gulf War in 1991 and am on Coumidin for life. What other type of medication can I possibly take if my counts go back up by the end of the month. Im suppose to take the Femera for 5 yrs. I ve only been on it for a yr. Help! Any suggestions?

doctor1 MD

what can causes central patperipheral and central neuropathic pain in right leg and groin area i am feamal

doctor1 MD

24 year old female with left lower back and sacroiliac pain, foot drop of the left foot with hyperreflexia and clonus also decreased sensation (light touch and pinprick) left lower lateral leg.... so my question is what are some of the possible differentials for these contrasting findings? will an UMNL cause peripheral manifestations and vice versa?