This last several months, my nipples get sore a lot . I have some fairly sized manbreasts, all my life really even when I was 25 at 150 pounds. But I have always had a large chest and neck. It s not painful but does bother me. A paternal first cousin had one nipple removed when he was a boy, would that be a cause of concern to me? I hope it s just from my shirt ( I only wear cotton knit shirts ) rubbing them. Maybe this happens more to woman, I don t know.