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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Sleeplessness After Using Phenelzine Antidepressant?

I was taking Tapentadol 2000 msg day and was given Phenalzine antidepressant. This resulted in me collapsing sleeping about 18 hours out of 24 and hospitalisation for 6 weeks. I have since found out I should not have been taking Tapentadol at the same time as an MAOI. Is this correct?
Tue, 20 Sep 2016
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Diabetologist,  's  Response
Yes you are correct. You shouldn't be taking tapentadol when you are beginning phenelzine. Phenelzine being a mono amine oxidase inhibitor has significant drug interaction with tapentadol. In most of the cases, a minimum of 14 days drug free gap is provided in between while mono amine oxidase inhibitor like phenelzine has to be introduced. I would suggest to take such medications only under physician guidance and as instructed.
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What Causes Sleeplessness After Using Phenelzine Antidepressant?

Yes you are correct. You shouldn t be taking tapentadol when you are beginning phenelzine. Phenelzine being a mono amine oxidase inhibitor has significant drug interaction with tapentadol. In most of the cases, a minimum of 14 days drug free gap is provided in between while mono amine oxidase inhibitor like phenelzine has to be introduced. I would suggest to take such medications only under physician guidance and as instructed.