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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Rheumatic Pain While On Sazo And HCQ Pill During Pregnancy?

Hi ,I am 8th month pregnant and taking sazo 1000 mg dailly half in morning half in evening, till my first trimester I was also taking hcqs 200mg. But right now I am having reumatic pain. Is it safe for me start the hcqs again along with sazo which i am already taking.
Wed, 2 Nov 2016
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General & Family Physician 's  Response
Hi & Welcome.

Avoid taking Sazo from now on wards.
Sazo seems be to not effective in controlling the pain associated with rheumatoid arthritis, so, you can start taking HCQ pill alone for the relief of pain in the rest of the pregnancy duration.

Sazo (Sulfasalazine) is a Pregnancy Category "B" drug which can be taken safely during first and third trimester of pregnancy. However, it may cause "kernicterus" (a type of brain damage) that occurs in a newborn with severe jaundice if taken in the last trimester or at term.

Sazo can displace bilirubin (a substance in the blood) from plasma protein albumin resulting in high levels of bilirubin which can spread into the brain tissues causing permanent brain damage.

Hydroxychloroquine (HCQ) appears to be safe during pregnancy hence can continue to take after consulting your treating doctor.

You also need to take iron and folic acid supplementation as prescribed by your gynecologist.

Hope these answer your query.
Best wishes.
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What Causes Rheumatic Pain While On Sazo And HCQ Pill During Pregnancy?

Hi & Welcome. Avoid taking Sazo from now on wards. Sazo seems be to not effective in controlling the pain associated with rheumatoid arthritis, so, you can start taking HCQ pill alone for the relief of pain in the rest of the pregnancy duration. Sazo (Sulfasalazine) is a Pregnancy Category B drug which can be taken safely during first and third trimester of pregnancy. However, it may cause kernicterus (a type of brain damage) that occurs in a newborn with severe jaundice if taken in the last trimester or at term. Sazo can displace bilirubin (a substance in the blood) from plasma protein albumin resulting in high levels of bilirubin which can spread into the brain tissues causing permanent brain damage. Hydroxychloroquine (HCQ) appears to be safe during pregnancy hence can continue to take after consulting your treating doctor. You also need to take iron and folic acid supplementation as prescribed by your gynecologist. Hope these answer your query. Best wishes.