I have un controlled bp 220/135 daily. I am taking .2 clonidine 3times a day. 20 mg of minoxidil, ramipril, carvedilol 12.5 two times a day. Spirolactone. They just uped the clonidine to the .2 three times a day. I normally take this at night and go to the bathroom about three times per evening, I have had high bp since I was a teenager. Cardiologist has run an mra to make sure blood vessels to kidney are not causing any problem. I am at a loss as to why this is so high. Any suggestions. Or is there better working medication that would help?