Since starting leflunomide to treat RA I ve experienced severe hot flashes accompanied by high anxiety and uncontrollable moodiness. My doctor tells me those are not side effects of the drug. My menopausal hot flashes finally ended about one year ago. These are something entirely different and much worse. I ve been taking leflunomide for nearly 3 months. Is what I m experiencing possibly caused from the drug or a drug interaction with something else I ve been prescribed?