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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Excessive Sweating Along With Heart Palpitations?

I was just told that I have a 114 level of chromogranin A. Does that mean I have cancer? My endocrinologist did the blood work because I was complaining of severe sweating and flushed face and sometimes heart palpitations. I currently take 88mcg of levothyroxine for an underactive thyroid and I thought my thyroid was out of wack. My thyroid function came back fine but the chromogranin a level came back at 114.
Wed, 12 Dec 2018
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Internal Medicine Specialist,  's  Response
Hello,

Chromogranin A is used as a marker for a tumour originating from neuroendocrine cells.

Chromogranin A in the blood and the range currently is less than 39ng/l. Abnormal levels can vary from forty to the thousands.

The sensitivity of the test for CgA is about 80%, this means that 80% of the time abnormal levels are correctly associated with the disease.

The specificity of the test is about 95%, this means that 95% of the time if the CgA level is normal and there is no disease present.

Chromogranin A levels can be spuriously elevated with sitting up oppose to lying down, hypertension, strenuous activity, pregnancy.

So don't worry repeat the test after a few weeks if the value is doubled then it may have more significance.

Please consult your endocrinologist he will examine and treat you accordingly.

Hope I have answered your query. Let me know if I can assist you further.

Take care

Regards,
Dr Penchila Prasad Kandikattu , Internal Medicine Specialist
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What Causes Excessive Sweating Along With Heart Palpitations?

Hello, Chromogranin A is used as a marker for a tumour originating from neuroendocrine cells. Chromogranin A in the blood and the range currently is less than 39ng/l. Abnormal levels can vary from forty to the thousands. The sensitivity of the test for CgA is about 80%, this means that 80% of the time abnormal levels are correctly associated with the disease. The specificity of the test is about 95%, this means that 95% of the time if the CgA level is normal and there is no disease present. Chromogranin A levels can be spuriously elevated with sitting up oppose to lying down, hypertension, strenuous activity, pregnancy. So don t worry repeat the test after a few weeks if the value is doubled then it may have more significance. Please consult your endocrinologist he will examine and treat you accordingly. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Penchila Prasad Kandikattu , Internal Medicine Specialist