I m a 42 year old female participating in Shires Clinical Research Study testing Vyvanse as a possible treatment for binge eating. I have been participating in the test since April 2014 (for the past 5 months) and I have been on 70 mg per day for the past four months without any serious side effects or issues. Over the past 8 days I have been experiencing severe migraine headaches. So severe they wake me up out of a sleep due to the pain. Today, during my routine follow up appointment, I spoke with the MD running the study and told him about these recent issues. I told him that I thought the migraines could possible be due to dramatic weather fluctuation (one day it s 80 degrees & humid and then within 12 hours the temp drops to 45 degrees). I told him I wasn t sure if I was experiencing a side effect to the Vyvanse or if it was caused by something unrelated. He then brought to my attention that my blood pressure which is normally around 120/78 (and was confirmed at my initial baseline testing prior to starting the study) has become elevated throughout the course of the study (it s in the 140/80-90 range) still normal range but has become increasing higher throughout the course of the study. Again, today I have suffered most of the day with another severe migraine attack. I am unable to get relief from 3 Motrin IB and 2 OTC migraine tablets, I m desperate for relief. I do not want to discontinue the study as It is has changed my life. But I also cannot function with severe migraine headaches, nausea, and lightheaded feelings. Can you recommend OTC treatment that could provide me with some relief. Unfortunately, I have a $5,000 deductible before my insurance provides any type of coverage (and I pay $600 per month for health insurance for my family) funds are limited, so a trip to the ER would exceeds my financial means. Any treatment suggestions would be welcomed and greatly appreciated.