Hello, Breast pain is common. And it can be classified into three categories cyclic, noncyclical, and extramammary. Clinically it is more important to differentiate between extramammary and true breast pain then between cyclic and noncyclic pain. This is because the management of cyclic and noncyclic breast pain is similar, while extramammary pain may require a different treatment. Cyclic breast pain is associated with hormonal fluctuations of the menstrual cycle, usually presenting in the week prior to the onset of menses. It is frequency both site and most severe in upper outer quadrant of the breast. Cyclical breast pain can also be associated with pharmacologic hormonal agent (e.g., oral contraceptive pills). Noncyclical breast pain, the pain does not follow the usual menstrual pattern, maybe constant or intermittent, and is more likely to be one site and variable in its location in the breast. It is more likely to be related to the breast or chest wall. Possible cause from large pendulous breast, high fat diet, smoking, and caffeine intake have been associated with breast pain, hormone replacement therapy, breast cysts, distention of subareolar duct in the breast due to inflammation unrelated to infection caused by penetration of the duct wall by lipid material, mastitis or breast abscess (red, warm, tender, swollen), inflammatory breast cancer (pain, firm, tender, enlarge breast) and others. Extramammary pain you may experience referred pain from sources other than the breast. Because there are the nerves branches to the breast. It is can be from musculoskeletal sources such as the chest wall, spinal or paraspinal disorders, trauma, or scaring form biopsy. It may also be related to a medical problem such as biliary, pulmonary, esophageal, or heart disease. For most women who present with breast pain, a thorough history and physical examination must be performed, and clinical judgement must be used in deciding upon any diagnostic imaging studies. But if no abnormality on physical examination or imaging studies, the risk for breast cancer is low at approximately 0.5 per cent. Such patients can be treated supportively. If there is a positive finding on imaging studies require appropriate follow up (e.g., biopsy). If your symptom persists you should go to see your doctor for further evaluation. Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Heang Chan Raksmey, General & Family Physician