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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Treatment For Mast Cell Disease

I have a friend with Mass cell disease who has gone everywhere and nobody is helping her. She is allergic to everything and goes into anaphylactic shock every day, all day. She s running out of options and doesn t know what to do. What are your suggestions and can a severe TBI cause this disease
Tue, 29 Mar 2016
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General & Family Physician,  's  Response
Hello dear,
Understand your concern.
Mast cell disease is a systemic disease due to excessive stimulation of mast cells.
Sign and symptoms are follow:
Fatigue, itching
Skin pigmentation-urticaria
Abdominal discomfort
Nusea, vomiting
Headache
Depression
Low blood pressor
Anaphylatic shock-breathlessness.

You should consult doctor.
Do skin and bone marrow biopsy.

CBC, ESR, TLC,DLC, PET scan.
Following are the treatments:
1. Antihistaminics drug-Cetrizine/loratadine
2. Leukotriene antagonist
3. Mast cell stabilizer-Cromoglycate
4. Proton pump inhibitor-Pantoprazole
5. Epinehrine, to open airway
6. Salbutamol inhaler
7. Corticostreois: prednisolone
8. Antidpressent if psychiatric symptoms- Doxepin tablet
9. Nifedipine: to decreased blood pressor
10. If sevre: Steroid plus chemotherapy , imetinab most commonly used.


Hope this may help you.
Best regards
Dr. Sagar
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Suggest Treatment For Mast Cell Disease

Hello dear, Understand your concern. Mast cell disease is a systemic disease due to excessive stimulation of mast cells. Sign and symptoms are follow: Fatigue, itching Skin pigmentation-urticaria Abdominal discomfort Nusea, vomiting Headache Depression Low blood pressor Anaphylatic shock-breathlessness. You should consult doctor. Do skin and bone marrow biopsy. CBC, ESR, TLC,DLC, PET scan. Following are the treatments: 1. Antihistaminics drug-Cetrizine/loratadine 2. Leukotriene antagonist 3. Mast cell stabilizer-Cromoglycate 4. Proton pump inhibitor-Pantoprazole 5. Epinehrine, to open airway 6. Salbutamol inhaler 7. Corticostreois: prednisolone 8. Antidpressent if psychiatric symptoms- Doxepin tablet 9. Nifedipine: to decreased blood pressor 10. If sevre: Steroid plus chemotherapy , imetinab most commonly used. Hope this may help you. Best regards Dr. Sagar