How much water do I need to be drinking on Harvoni? Experiencing extreme fatigue, moderate headache 24/7 and loose bowels for about a week. At beginning of treatment which began 4 weeks ago, my viral load count was 1.2 million, which is the same as it was and has been since I was first diagnosed in 2009. I know i contracted the disease when I was 19 (66 now), because my twin brother had acute symptoms at that age and off and on over the years, even with interferon/ribaviran treatments every few years since 1985. In other words, his case was much more severe than mine. He passed away on November 13, 2011 at age 62, cause unknown. His autopsy confirmed moderate-severe cirrhosis, but he already knew about that. About 2 weeks prior to beginning the Harvoni treatment, I had all my teeth extracted and will receive my dentures about a month after I finish Round 2 of the Harvoni treatment (in about 3 weeks). I know my primarily liquid diet of fruit and green powder/turmeric added smoothies is a factor in my fatigue problem. I am always hungry, but I m not losing weight. Is 80 ounces of water daily enough and do you have any dietary recommendations that might help. My poor little Shiatsu puppy needs a walk.