Thanks for your question on Healthcare Magic. I can understand your concern. Pyzina is having pyrazinamide. Mycobutol is having ethambutol. Both of them can cause rise in uric acid level (hyperuricemia). This high uric acid can accumulate in joints and cause joint pain. It can also cause fever with chills. So in my opinion, she should get done uric acid level and if it is raised then she needs to take febuxostat tablet. Febuxostat is having property of reduced uric acid production. So consult her doctor and discuss all these. Hope I have solved your query. I will be happy to help you further. Wishing good health to your wife. Thanks.