Hi. Thanks for your query. The reasons of your symptoms of bloating, tiredness and no energy to exercise can be due to the following factors: -Estrogen replacement can be the first reason itself as it alters the body s physiology. -Also has direct effect on Psychology and so on. It is possible that you may need to get altered dosage after talking to your Doctor. -Zoloft- Sertaline also has side effects of weight gain as this is amitryptiline group and you seriously need to talk to your treating Doctors . -Local causes can be intestinal disturbed flora which can be easily corrected by taking pre and probiotics. -Or if possible you should take another / second opinion of an another Doctor to have detailed sessions of psychotherapy and change of medicines. -Get some tests : Hormonal levels, thyroid functions, blood sugar, Electrolytes.