My wife is 74 years old and has a long record of major depression over the last 15 years. She has be on and off depression during that time. As far as medication that worked: Cymbalta and Wellbutrin for about 5 years. Currently she is only on Cymbalta but that has done little to help with her major depression. Her doctor yesterday suggested to go to Vybrid starting @10mg working her way up to 40mg. I asked the pharmacist for her opinion and she said that they very few patients on this drug since it was comparatively new.