My rheumatologist has indicated that he would like me to start the Prolia injections due to an increase in my osteoporosis of the spine. I have been on most of the pill forms for years, the last one being the generic actonel (with several "vacations"). I take many vitamins, as well as BP medicine once daily and 81 mg ASA once every other day. I am 72 years old. Take only 2 arthritis strength pills AM, 2 PM and my milk thistle to protect my liver. I have not had a specific consultation with this physician regarding side effects yet. This is because I am new to him as a patient, due to my former rheumatologist having to close his practice due to illness. I am concerned with a drug interaction with my vitamins but also many of the side effects of this injection. What might one expect? I fully realize that every possible side effect known to mankind must be listed on these drugs. What is the percentage of people having side effects? Thank you.