Thanks for writing in.
Neither medical nor surgical interventions for knuckle pads are very effective. Eliminating the source of mechanical or repetitive trauma may improve the lesions. Injections of corticosteroids
may reduce the size of the pads. Application of silicone gel sheeting has had limited success. Applications of keratolytics, such as salicylic acid
or urea, have helped to soften and even reduce the lesions. Radiation
therapy and application of solid carbon dioxide have been reported to be of some help in selected cases.
Please discuss above options with your doctor.
Hope this helps