Hi, dear I have gone through your question. I can understand your concern. You have history of fissure and piles. Procto glyvenol cream is safe and you can use it for piles. It gives symptomatic relief in piles. You should avoid constipation. For that you should drink plenty of water and eat green leafy vegetables and high fiber diet. Liquid duphalac at night is useful. Hope I have answered your question. If you have any doubts then feel free to ask me. I will be happy to answer. Thanks for using health care magic. Wish you a very good health.