Hi and thank you so much for this query. I am so sorry to hear about this rising INR levels. The recent rise in the numbers show that either there is something in your diet or drugs is responsible for this. There are two approaches to this, may be to switch you off the glimepiride that coincides with this rising numbers and see whether it returns to normal. If it should, then your doctor may want to use a different drug to address your diabetes. However, if it shouldn t, then it may just be time for your dosage to be reduced. it is easier to manipulate the dosage of your drug than your diet. After eating all what the doctor recommended, should the test return normal, would you be able to live like that all your life? The answer is no. I will suggest that your doctor should rather try to adapt the dosage to every other changes and not otherwise because of the difficulty to manipulate the other aspects. I hope this helps. I wish you well. Thanks for using our services and feel free to request for more information. Thanks. Dr. Ditah, MD.