Hello, Lupron is recommended for large fibroids to shrink them in size so they are easier removed with less invasive procedures such as laparoscopically. every medication has its possible side effects, but I think the doctor has already weighed the pros and cons and has considered this the best course of action. On the other hand, even if the fibroids shrink, you will need to have them removed because after stopping the treatment, they grow back to the previous size. I hope this answers your query. Let me know if I can assist you further. Regards, Dr. Antoneta Zotaj, General & Family Physician