Hello! Thank you! My grand daughter was born 1 year ago with several symptoms that point to a rare genetic mutation. - a whole in the heart - low weight at birth- small kidneys, small brain for her skull, which leave a gap between the brain and the skull- no lines on the palms of her hands- a crooked line between the back of her waist and her coxis- no crawling- not saying a word. My daughter has medical insurance, she had gone to many doctors and done many medical tests and an MRI and no doctor till now could put the pieces of the puzzle together, so, they don´t have a diagnosis.