I am not the patient ... what could this do to kidneys if use for a long time ? She chews them and take all meds at one time .. takes at night She takes losartan 100 mg, tramadol 50 mg, clindamycin 150mg, ( sulfasalazine 500 mg ) , atorvastatin 40 mg, escitalopram 10 mg , clopidogrel 75 mg ,, hand full of vitamins and a lot of Tyrol .. She is tired, has Hot flashes And dry mouth ... this is taken for arthritis and colitis ... Think she could at least cut back..?