When taking pain killers on a full stomach or with appropriate amounts of food, Is it still harmful for your stomach in the long run. I take meloxicam, for osterarthiritis. Even though, it was prescribed for taking one tablet a day. I may take one when the pain is severe, and I make sure I have food on my stomach. Is it still dangerous enough to mess hurt my stomach by causing preferations there? I don t take them often, only when the pain is bad. Thanking you in advance for your answer.