Casudex (bicalutamide) should be initiated at least 3 days before Lupron (leuprolide) shot in advanced prostate cancer with metastasis.It is also continued after Lupron is administered. In your case, casudex is started 2 weeks before and also continued for 2 weeks after Lupron short which appears logical. Please adhere to the prescribed regimen of drugs as prescribed by your oncologist for optimum outcomes. Hope this helps. Thanks.