Crusty, sore, painful nose. No, I do not use drugs. I have COPD (severe) as well as high blood pressure. On Advair, Albuterol, Amlodipine, Labetalol, and Lipitor. 62 yr old female, 92 lbs. I thought it was being caused by the Labetalol interacting in a bad way with the Advair and Albuterol. But I go through 6 large boxes of Kleenex a week. Blowing my brains out. And now I continue to try and pick all the crustation out of my nose all day and night, hoping to breathe better. Lots of blood also. Can you help or advise?