Hi, Thanks for writing in. Cancer is a difficult condition to treat and depends on the individual case. Your husband had a surgery followed by chemotherapy that has been on for last 6 months. It is possible that due to side effects of chemotherapy he is unable to have a good meal because of lack of appetite. Along with inability to eat there is also decreased liquid and water intake in many people on treatment with chemotherapy. In this situation you must see that he has an adequate fluid intake of 2.5 liters every day to keep his hydration normal. Since a colon cancer can cause liver spread in half of the patients therefore complete follow up is required and ultrasound scans and CT scan might help. Regarding his talking irrelevantly, it is important to know if his serum electrolytes are normal as you have said about his possibility of dehydration. Please get his sodium, chloride, calcium and potassium levels checked. He also has little amount of anxiety that is present due to continuous treatment and not being able to lead a normal life. A spread to brain is less likely if you think about the way he is behaving. If he continues to behave this way and his electrolytes are normal then consult a neurologist. Please do not worry.