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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can One Become Immune To Zoloft After A While?

My husband, age 70 has been taking 50 mg. of zoloft for anxiety for about 20 years. Doesn t seem to be working as well. Has he built a tolerance? Should he ask his doctor to increase the dosage? He s also recently (2 months)n quit smoking which increases anxiety.
Mon, 29 Dec 2014
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Internal Medicine Specialist 's  Response
hi,
Yes, zoloft (an antidepressant) can develop tolerance over time, especially on long term usage. If it seems to be slowing down, either its dose needs to be increased or other replacements (like dotheipein or mirtaz) should be sought.
Consult your doctor who will address your problem.
All the best.
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Can One Become Immune To Zoloft After A While?

hi, Yes, zoloft (an antidepressant) can develop tolerance over time, especially on long term usage. If it seems to be slowing down, either its dose needs to be increased or other replacements (like dotheipein or mirtaz) should be sought. Consult your doctor who will address your problem. All the best.