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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Can Clopidogrel Be Taken While On Prilosec?

I have heart issues. Previously I had a quadruple heart bypass (2003) and a open heart aortic valve replacement (2015). I just was weaned off Warfarin, and my doctor just prescribed Clopidogrel. The doctor has me take some aspirin every day (even when I was on warfarin). I was just reading the article on this website about Clopidogrel and it states that the Prilosec that I have been taking daily for 15 years might be a problem with this medication. (If I forget to take it one day, I get horrible heart burn) What do you think????
Mon, 19 Feb 2018
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Cardiologist,  's  Response
Hello,

Firstly, why were you weaned off of Warfarin, was it a bioprosthetic aortic valve? And what was a need to change from aspirin. Yes, sometimes Prilosec decrease the efficacy of Clopidogrel in some patients. This is not universal. You can have Ranitidine 150 mg twice a day instead of Prilosec, which doesn't have this problem. If there is no compelling need it'd better to continue aspirin.

Hope this helps you and get back if you have any doubts.


Take Care

Regards,
Dr. Sagar Makode,
Cardiologist
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Can Clopidogrel Be Taken While On Prilosec?

Hello, Firstly, why were you weaned off of Warfarin, was it a bioprosthetic aortic valve? And what was a need to change from aspirin. Yes, sometimes Prilosec decrease the efficacy of Clopidogrel in some patients. This is not universal. You can have Ranitidine 150 mg twice a day instead of Prilosec, which doesn t have this problem. If there is no compelling need it d better to continue aspirin. Hope this helps you and get back if you have any doubts. Take Care Regards, Dr. Sagar Makode, Cardiologist