Is confusion and forgetfulness a sign brain lesions ? Patient stage 4 lung cancer, WITH past metastasis to brain. Cyber knife helped, 12 months later back in numerous areas of brain. On oxygen, was at 65. Has also had heavy chemo, radiation and immune therapy. Been 16 months..still can t accept it. S h e is 72... lesions in liver, anus, on bones, lungs and lymph nodes. Had headaches, but can confusion be a symptom, as.well as comprehension? Oncologist rec.hospice...she won t even think about it.