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Suggest Treatment For Dysphonia And Discoordination In The Muscles

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Posted on Wed, 3 Aug 2022
Question: I’ve been under investigation for dysphagia for two years; I’ve also developed some dysphonia in the past year or so. I’ve had many tests, most of them showing some discoordination in the muscles used for swallowing, but they can’t pinpoint a pattern that would lead to a specific diagnosis (like achalasia). I recently had a blood test for acetylcholine receptor antibodies, and the result popped up online, but I have not been contacted by my doctor yet. The result was <.20. Could you please help me interpret that? Thank you.
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Answered by Dr. Mirjeta Guni (45 minutes later)
Brief Answer:
About acethylcholine antibodies

Detailed Answer:

Hello,

Myasthenia Gravis is one of the pathologies that causes dysphagia due to the presence of acethylcholine antibodies (binding or blocking antibodies) that block the effect of this neurotransmitter and as a result the muscles do not contract normally.
The result you reported means that the antibodies are negative, when they result over 0.5 nMol/ L are considered positive.
So, myasthenia is excluded as a cause of the dysphagia.

Hope the information will help.
Regards,
Dr. Mirjeta
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Above answer was peer-reviewed by : Dr. Yogesh D
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Answered by
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Dr. Mirjeta Guni

Endocrinologist

Practicing since :2006

Answered : 2414 Questions

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Suggest Treatment For Dysphonia And Discoordination In The Muscles

Brief Answer: About acethylcholine antibodies Detailed Answer: Hello, Myasthenia Gravis is one of the pathologies that causes dysphagia due to the presence of acethylcholine antibodies (binding or blocking antibodies) that block the effect of this neurotransmitter and as a result the muscles do not contract normally. The result you reported means that the antibodies are negative, when they result over 0.5 nMol/ L are considered positive. So, myasthenia is excluded as a cause of the dysphagia. Hope the information will help. Regards, Dr. Mirjeta