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Is There Interaction Between Oxycodone And Propranolol?

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Posted on Thu, 7 Jul 2016
Question: Hello, Is it safe or are there drug interactions with 5mg of oxycodone with 20mg of propranalol?
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Answered by Dr. Panagiotis Zografakis (1 hour later)
Brief Answer:
they may interact to cause low blood pressure

Detailed Answer:
Hello,

propranolol lowers the blood pressure and heart rate. Oxycodone may potentiate the effect on blood pressure. Using both is not prohibited but caution is required to avoid untoward effects like postural hypotension.Dose escalation should be gradual. The doses you've mentioned are not very high, so the interaction is expected to be less important. There's no way to predict it though, for any particular individual.

Since both types of drugs are commonly used, I can add that most patients do not experience serious problems but caution is required when initiating the combination.

Kind Regards!

Note: For more detailed guidance, please consult an Internal Medicine Specialist, with your latest reports. Click here..

Above answer was peer-reviewed by : Dr. Chakravarthy Mazumdar
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Answered by
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Dr. Panagiotis Zografakis

Internal Medicine Specialist

Practicing since :1999

Answered : 3810 Questions

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Is There Interaction Between Oxycodone And Propranolol?

Brief Answer: they may interact to cause low blood pressure Detailed Answer: Hello, propranolol lowers the blood pressure and heart rate. Oxycodone may potentiate the effect on blood pressure. Using both is not prohibited but caution is required to avoid untoward effects like postural hypotension.Dose escalation should be gradual. The doses you've mentioned are not very high, so the interaction is expected to be less important. There's no way to predict it though, for any particular individual. Since both types of drugs are commonly used, I can add that most patients do not experience serious problems but caution is required when initiating the combination. Kind Regards!