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Hi, I Wonder If Valproate + Lacosamide Is A Safe
Question: Hi,
I wonder if Valproate + Lacosamide is a safe combination. My neurologist insists the combination is fine, but it led to some awful side effects for me. Also, I found a few articles saying that the combination can lead to brain damage.
I wonder if Valproate + Lacosamide is a safe combination. My neurologist insists the combination is fine, but it led to some awful side effects for me. Also, I found a few articles saying that the combination can lead to brain damage.
Hi,
I wonder if Valproate + Lacosamide is a safe combination. My neurologist insists the combination is fine, but it led to some awful side effects for me. Also, I found a few articles saying that the combination can lead to brain damage.
I wonder if Valproate + Lacosamide is a safe combination. My neurologist insists the combination is fine, but it led to some awful side effects for me. Also, I found a few articles saying that the combination can lead to brain damage.
Brief Answer:
Combination of valproate and lacosamide is safe.
Detailed Answer:
Hi,
Thank you for posting your query.
I have noted your clinical details and your current medications. Valproate and lacosamide combination is safe. There are no significant drug interactions and the combination does not lead to brain damage.
However, if you are facing adverse effects, you could switch back to levetiracetam instead of lacosamide.
I hope it helps. Please get back if you have any follow-up queries.
Best wishes,
Dr Sudhir Kumar MD DM
Consultant Neurologist
Apollo Hospitals, XXXXXXX
Combination of valproate and lacosamide is safe.
Detailed Answer:
Hi,
Thank you for posting your query.
I have noted your clinical details and your current medications. Valproate and lacosamide combination is safe. There are no significant drug interactions and the combination does not lead to brain damage.
However, if you are facing adverse effects, you could switch back to levetiracetam instead of lacosamide.
I hope it helps. Please get back if you have any follow-up queries.
Best wishes,
Dr Sudhir Kumar MD DM
Consultant Neurologist
Apollo Hospitals, XXXXXXX
Above answer was peer-reviewed by :
Dr. Yogesh D
Brief Answer:
Combination of valproate and lacosamide is safe.
Detailed Answer:
Hi,
Thank you for posting your query.
I have noted your clinical details and your current medications. Valproate and lacosamide combination is safe. There are no significant drug interactions and the combination does not lead to brain damage.
However, if you are facing adverse effects, you could switch back to levetiracetam instead of lacosamide.
I hope it helps. Please get back if you have any follow-up queries.
Best wishes,
Dr Sudhir Kumar MD DM
Consultant Neurologist
Apollo Hospitals, XXXXXXX
Combination of valproate and lacosamide is safe.
Detailed Answer:
Hi,
Thank you for posting your query.
I have noted your clinical details and your current medications. Valproate and lacosamide combination is safe. There are no significant drug interactions and the combination does not lead to brain damage.
However, if you are facing adverse effects, you could switch back to levetiracetam instead of lacosamide.
I hope it helps. Please get back if you have any follow-up queries.
Best wishes,
Dr Sudhir Kumar MD DM
Consultant Neurologist
Apollo Hospitals, XXXXXXX
Above answer was peer-reviewed by :
Dr. Yogesh D
Brief Answer:
Seizure are episodic by nature and many factors are involved in its genesis
Detailed Answer:
Thank you for getting back with more information.
Seizures are episodic and the seizure frequency needs to observe over a long period of time (at least 3-6 months) to draw significant conclusions. I have seen patients who have totally skipped medicines for one or more without seizures, and suddenly getting 2-3 seizures in a few days after that.
Other than the choice of anti-epileptic drugs and their doses, many other factors can influence the occurrence of seizures, such as 1. Sleep deprivation, 2. Fasting or delayed meals, 3. Stress or anxiety, 4. Fever, etc.
In summary, in shorter periods, one may not see a correlation between lower doses and seizure frequency. However, one must use the lowest effective (and safe) dose to reduce seizure frequency over longer periods of time.
Best wishes,
Dr Sudhir Kumar MD DM
Seizure are episodic by nature and many factors are involved in its genesis
Detailed Answer:
Thank you for getting back with more information.
Seizures are episodic and the seizure frequency needs to observe over a long period of time (at least 3-6 months) to draw significant conclusions. I have seen patients who have totally skipped medicines for one or more without seizures, and suddenly getting 2-3 seizures in a few days after that.
Other than the choice of anti-epileptic drugs and their doses, many other factors can influence the occurrence of seizures, such as 1. Sleep deprivation, 2. Fasting or delayed meals, 3. Stress or anxiety, 4. Fever, etc.
In summary, in shorter periods, one may not see a correlation between lower doses and seizure frequency. However, one must use the lowest effective (and safe) dose to reduce seizure frequency over longer periods of time.
Best wishes,
Dr Sudhir Kumar MD DM
Above answer was peer-reviewed by :
Dr. Yogesh D
Brief Answer:
Seizure are episodic by nature and many factors are involved in its genesis
Detailed Answer:
Thank you for getting back with more information.
Seizures are episodic and the seizure frequency needs to observe over a long period of time (at least 3-6 months) to draw significant conclusions. I have seen patients who have totally skipped medicines for one or more without seizures, and suddenly getting 2-3 seizures in a few days after that.
Other than the choice of anti-epileptic drugs and their doses, many other factors can influence the occurrence of seizures, such as 1. Sleep deprivation, 2. Fasting or delayed meals, 3. Stress or anxiety, 4. Fever, etc.
In summary, in shorter periods, one may not see a correlation between lower doses and seizure frequency. However, one must use the lowest effective (and safe) dose to reduce seizure frequency over longer periods of time.
Best wishes,
Dr Sudhir Kumar MD DM
Seizure are episodic by nature and many factors are involved in its genesis
Detailed Answer:
Thank you for getting back with more information.
Seizures are episodic and the seizure frequency needs to observe over a long period of time (at least 3-6 months) to draw significant conclusions. I have seen patients who have totally skipped medicines for one or more without seizures, and suddenly getting 2-3 seizures in a few days after that.
Other than the choice of anti-epileptic drugs and their doses, many other factors can influence the occurrence of seizures, such as 1. Sleep deprivation, 2. Fasting or delayed meals, 3. Stress or anxiety, 4. Fever, etc.
In summary, in shorter periods, one may not see a correlation between lower doses and seizure frequency. However, one must use the lowest effective (and safe) dose to reduce seizure frequency over longer periods of time.
Best wishes,
Dr Sudhir Kumar MD DM
Above answer was peer-reviewed by :
Dr. Yogesh D
Thank you for your answer!
I have another question. When I started taking 300mg morning and 300mg evening of Valproate, I started having seizures (I hadn't had one since autumn). When I quit taking levetiracetam, I had more seizures and my head felt like it was burning. My neurologist asked me to increase valproate to 300mg + 450mg and that made the situation worse; My head burned more, I had more seizures and started having memory problems.
I panicked and decreased valproate to 150mg + 300mg, and my seizures went away (I also added 250mg levetiracetam morning and evening). I tried decreasing valproate to 150mg twice per day. My seizures did not return. However, my sleeping got completely ruined as well (I did this without adding additional levetiracetam since my neurologist said that it could be dangerous to add more of it).
All the while I have been taking lacosamide without altering the dose.
How can I interpret the fact that my seizures did not return despite subpar dosages of both valproate and levetiracetam?
I have another question. When I started taking 300mg morning and 300mg evening of Valproate, I started having seizures (I hadn't had one since autumn). When I quit taking levetiracetam, I had more seizures and my head felt like it was burning. My neurologist asked me to increase valproate to 300mg + 450mg and that made the situation worse; My head burned more, I had more seizures and started having memory problems.
I panicked and decreased valproate to 150mg + 300mg, and my seizures went away (I also added 250mg levetiracetam morning and evening). I tried decreasing valproate to 150mg twice per day. My seizures did not return. However, my sleeping got completely ruined as well (I did this without adding additional levetiracetam since my neurologist said that it could be dangerous to add more of it).
All the while I have been taking lacosamide without altering the dose.
How can I interpret the fact that my seizures did not return despite subpar dosages of both valproate and levetiracetam?
Thank you for your answer!
I have another question. When I started taking 300mg morning and 300mg evening of Valproate, I started having seizures (I hadn't had one since autumn). When I quit taking levetiracetam, I had more seizures and my head felt like it was burning. My neurologist asked me to increase valproate to 300mg + 450mg and that made the situation worse; My head burned more, I had more seizures and started having memory problems.
I panicked and decreased valproate to 150mg + 300mg, and my seizures went away (I also added 250mg levetiracetam morning and evening). I tried decreasing valproate to 150mg twice per day. My seizures did not return. However, my sleeping got completely ruined as well (I did this without adding additional levetiracetam since my neurologist said that it could be dangerous to add more of it).
All the while I have been taking lacosamide without altering the dose.
How can I interpret the fact that my seizures did not return despite subpar dosages of both valproate and levetiracetam?
I have another question. When I started taking 300mg morning and 300mg evening of Valproate, I started having seizures (I hadn't had one since autumn). When I quit taking levetiracetam, I had more seizures and my head felt like it was burning. My neurologist asked me to increase valproate to 300mg + 450mg and that made the situation worse; My head burned more, I had more seizures and started having memory problems.
I panicked and decreased valproate to 150mg + 300mg, and my seizures went away (I also added 250mg levetiracetam morning and evening). I tried decreasing valproate to 150mg twice per day. My seizures did not return. However, my sleeping got completely ruined as well (I did this without adding additional levetiracetam since my neurologist said that it could be dangerous to add more of it).
All the while I have been taking lacosamide without altering the dose.
How can I interpret the fact that my seizures did not return despite subpar dosages of both valproate and levetiracetam?
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