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Crigler-Najjar syndrome is a rare inherited disorder in which bilirubin
(a substance made by the liver) cannot be broken down due to which bilirubin can build up in the body and lead to jaundice
(yellow discoloration of skin and eyes) and damage to the brain, muscles, and nerves.
It is of two types:
Type I : Occurs early in life
Type II : Occurs during adolescent age
1. Confusion and changes in thinking
2. Yellow skin (jaundice) and yellow in the whites of the eyes (icterus)
1. Light treatment (phototherapy
) is needed on a regular basis throughout life.
2. Liver transplantation
has been used successfully in some people with type 1 disease.
3. Blood transfusions may help control the amount of bilirubin in blood plasma
4. The drug phenobarbitol is sometimes used to treat type 2.
Hope this answers helps