Hi welcome to HCM, I am Dr. Das
Sickle cell anemia is an inherited abnormality in production of hemoglobin
. In this disease the normal biconcave shape of RBC
is changed into Sickle shape due to mutation
in the gene responsible for hemoglobin synthesis. it leads to obstruction of microcirculation and hemolytic anemia
Now, there is 2 conditions related to this disease. One is homozygous state where patient has total inability to form normal hemoglobin and a heterozygous state where patient has mild inability to form normal Hemoglobin.
Transmission of this disease depends on both the parents. If one is homozygous and other is normal then chance of the baby to have the disease is 100%. If one is heterozygous and other is normal then chance of the baby to get the disease is 50%.
so, you have to know the genetic status of you and your girlfriend. Only then the chance of your baby to have this disease can be said.