Hi ! Good evening. I am Dr Shareef answering your query. Even though chances of STD are remote because of your monogamous relationship with your wife, I being a doctor would advise you to under go tests for it after getting it physically examined by a dermatologist in your area to rule this out. The lumpish swelling could also be due to friction and the foreskin attachment with the penile shaft being pulled up causing a small hematoma in there. This could be said with certainity only after getting physically examined by a doctor. If you are using astroglide for the first time, sensitivity to this reagent can not be excluded. Whatever it could be, I would advise you to get your self reviewed by your family physician/dermatologist to arrive at a particular diagnosis. I hope this information would help you in discussing with your family physician/treating doctor in further management of your problem. Please do not hesitate to ask in case of any further doubts. Thanks for choosing health care magic to clear doubts on your health problems. Wishing you an early recovery. Dr Shareef.