Hi, Night sweats is the occurrence of excessive sweating during sleep. It can occur due to infection, hormonal imbalance, cancer, psychological conditions, drug induced and several other causes. Considering his age, psychological morbidity and treatment following are possible causes which need to rule out in his case: -Hot sleeping environment: Hope it is not in his case -Residual anxiety and depression -Hyperthyroidism: It is also associated with anxiety. For evaluation get his serum T3/T4/TSH done on empty stomach. -Autonomic over-activity: common in anxiety and hyperthyroidism. -Substance use like alcohol and heroine Although night sweats can occur with Sertraline but in clinical population it is rare. It is better to rule out above condition first as a cause for night sweats. Following situation will favor night sweats due to Sertraline: -If it is started after initiating treatment with Sertraline. -If it is stopped within 2 weeks of reducing doses or terminating treatment with Sertraline. I hope this information has been both informative and helpful for you. In case of any doubt, I will be available for follow ups. Wish you good health. Regards, Dr. Ivan R. Rommstein, General Surgeon