A 35 year old patient is investigated for anemia. He complained as well from headache, body, back, loin, and joint pain with heartburn and dysuria. The blood film shows target cells. Which one of the following is a probable cause? A. Haemolytic uraemic syndrome, B. Paroxysmal noctural haemoglobinuria, C. Thalassemia, D. Haemochromatosis, E. Impending renal impairment