Alpha Thalassemia should not cause symptoms. However, over the years I have had many of the symptoms from birth and during my adult life. Added to those complications sickle cell anemia trait also exits. I can go for a good for a couple of hours and crash for days. These conditions have taken a toll leaving me amongst other things extremely fatigue. No matter how I try to keep up my health with supplements and other building blocks, I seem to lose the battle to severe tiredness. Thalassemia of any variant should not be under sold when not in full major. Each patient should be evaluated accordingly on their health merits and not directly what others think should not occur based on the mildness. Do you have any suggestions for me in overcoming the exhaustive crashes ? The other symptoms like shortness of breath etc., I am still in the learning process of how to control them. Oh by the way your response would be I have a Heart To Pass On God s Greatness because of the inability to work. One day I look forward to paving and paying forward I have a Heart To Pass On God s Greatness . Thanks in advance for your generosity!