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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Enlarged Spleen While Having Hereditary Spherocytosis?

I have hereditary spherocytosis and I had my gallbladder taken out when I was 11, I am 14 right now. I weigh about 160 and It is 3:00 am in the morning right now and My spleen is enlarged, right now it is hurting, I can not jump or stand because it hurts, I just don't know what is wrong and I am scared, please help?
Mon, 4 May 2015
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General & Family Physician,  's  Response
Dear

I really appreciate your concern for the enlarged spleen and its discomfort.

Hereditary spherocytosis is due to genetic defect in erythrocyte ( red blood cell) membrane proteins result in erythrocyte instability resulting in production of spherical red blood cells (spherocytes), which are removed rapidly from the circulation by the spleen.

Hemolysis (break down of spherocytes) primarily is confined to the spleen resulting in enlarged spleen.

If the enlarged spleen is hurting you a lot then visit your treating doctor for possible treatment involving removal of spleen (splenectomy).

Hope this advice will help you in seeking the relief from the discomfort caused by the enlarged spleen.

Wishing you best of your health.

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What Causes Enlarged Spleen While Having Hereditary Spherocytosis?

Dear I really appreciate your concern for the enlarged spleen and its discomfort. Hereditary spherocytosis is due to genetic defect in erythrocyte ( red blood cell) membrane proteins result in erythrocyte instability resulting in production of spherical red blood cells (spherocytes), which are removed rapidly from the circulation by the spleen. Hemolysis (break down of spherocytes) primarily is confined to the spleen resulting in enlarged spleen. If the enlarged spleen is hurting you a lot then visit your treating doctor for possible treatment involving removal of spleen (splenectomy). Hope this advice will help you in seeking the relief from the discomfort caused by the enlarged spleen. Wishing you best of your health.