Hello... thanks for choosing healthcare magic for your query. I understand your concern about your wife. As urine pregnancy test is negative then it is least likely that she is pregnant. By looking at her symptoms and less bleeding during menses it is highly recommended to do ultra TSH, S. Prolactin and USG abdomen and pelvis and get treatment if needed. If the symptoms are before menses only , about one week prior menses, and relieves after or with menses then it is premenstrual syndrome. For PMS ( premenstrual syndrome) she needs to work on overall health both mental and physical like some kind exercise for one hour ,yoga preferred, diet modifications good vit D3 and calcium rich diet meditation if it doesn t relieve then some medications needs to start. But first of try these non medical options which are long lasting. If she also has crying spells, decreased energy, sleep disturbance, low moods then think about her mental health. I hope this helps. Feel free to contact again if any query. Regards, DR TEJASHREE BHOR GYNAECOLOGIST, DHANORI, PUNE.