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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Blackening Skin After Increasing The Paxidep Dosage?

I m using pexidep cr 12.5mg one tab daily since one month before one month I using pexidep 25 mg daily three month,now this time my neck arm and some part of body skin going black,so how to solve it and I want to leave this medicine how its possible
Mon, 25 May 2015
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Psychiatrist,  's  Response
Hello thanks for asking from HCM for your health related queries

I can understand your concern. Paxidep is controlled release formulation of Paroxetine which is a SSRI drug. The drug is a good drug for depression and anxiety and is safe to use. It is not very common to see dermatological side effects with this drug. You have developed blackening of skin with this drug so I would advise you to please visit a dermatologist to find out exactly if the skin symptoms are occurring due to Paroxetine or not.

The drug should never be stopped abruptly as this may result in withdrawal symptoms so doses should be reduced gradually over 6-10 weeks by reducing the doses by 20-25% every two weeks. Tapering the doses in this manner prevent any withdrawal symptoms. Please report to your doctor for any side effects you are having.

Thanks, Hope this helps you. Take care.

Dr. Seikhoo Bishnoi
MD Psychiatry
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What Causes Blackening Skin After Increasing The Paxidep Dosage?

Hello thanks for asking from HCM for your health related queries I can understand your concern. Paxidep is controlled release formulation of Paroxetine which is a SSRI drug. The drug is a good drug for depression and anxiety and is safe to use. It is not very common to see dermatological side effects with this drug. You have developed blackening of skin with this drug so I would advise you to please visit a dermatologist to find out exactly if the skin symptoms are occurring due to Paroxetine or not. The drug should never be stopped abruptly as this may result in withdrawal symptoms so doses should be reduced gradually over 6-10 weeks by reducing the doses by 20-25% every two weeks. Tapering the doses in this manner prevent any withdrawal symptoms. Please report to your doctor for any side effects you are having. Thanks, Hope this helps you. Take care. Dr. Seikhoo Bishnoi MD Psychiatry