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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Autoimmune Hepatitis , Lupus And Rheumatoid Arthritis?

I have been diagnosed with autoimmune hepatitis, lupus, rheumatoid arthritis and mixed connective tissue disease in 2011. I am currently taking azathioprine, folic acid, calcium/vitamin D, vitamin B12, sertraline, prednisone. The prednisone have been off for about 3 weeks and yesterday and the night before I have been getting real dizzy nauseated and really run down. So I went in to the DR they checked my blood and my two liver levels are a 125 &129. The doctor gave me a shoot of a steroid and today I will start taking prednisone 60mg for five days and then 40mg for five days then 20mg for five days until I can get in with my specialist in November. Is my liver levels considered high?
Thu, 14 May 2015
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Orthopaedic Surgeon,  's  Response
Dear patient
Your liver enzyme levels are high as normal upper level is 40. Yours is almost three times higher. This is due to hepatic cells damage and may be side effect of azathioprine. You need to consult your doctor for revising the dose or switch over to other non hepatotoxic drug. Prednisonolone causes severe withdrawal symptoms on sudden stoppage and hence should be stopped gradually.
All the best.
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What Causes Autoimmune Hepatitis , Lupus And Rheumatoid Arthritis?

Dear patient Your liver enzyme levels are high as normal upper level is 40. Yours is almost three times higher. This is due to hepatic cells damage and may be side effect of azathioprine. You need to consult your doctor for revising the dose or switch over to other non hepatotoxic drug. Prednisonolone causes severe withdrawal symptoms on sudden stoppage and hence should be stopped gradually. All the best.