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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Cause Elevated Level Of Cholesterol?

I am 33, 6 4, I range from 200-213 lbs. Not sure what I was last time I was weighed. My Cholesterol was 299 this past March. I have varicose veins in my right leg for a long time with no real problems or irritation. Last Thursday (12-8) I took 60mg vyvanse at 7:30am to help study. I ve taken it before with no problems besides the normal side effects. Loss of appetite, some insomnia b/c of the time I took, and dry mouth. I am not prescribed the vyvanse. I got it from a friend. I know I shouldn t do that but I did. When I took the vyvanse this past Thursday, I had a little pain in my calf where I have a varicose vein. Didn t think much of it. Friday 12-9, I worked and went out for my b-day. I felt the same pain in the calf when walking at work. Didn t feel the pain Friday night probably due to the alcohol I drank. Saturday I could feel the pain in my calf and also to my inner thigh about 2 inches above the knee where more varicose veins are. When I don t move my leg I feel no pain, When I get up and start walking I feel it like a sore muscle but after moving around its little pain. I played volleyball Saturday night 12-10. Between games I am sitting waiting for the next game. I get up to play and I feel sore from calf to thigh but when playing and moving around I m fine. Sunday was the worse pain.Both calves, shoulder and arms were sore due to being inactive and then playing volleyball. While sitting down at work I felt the pain a little but when I get up to walk, I was limping until I walked it off. All the pain radiated from the varicose vein in my calf to my varicose vein on my inner thigh. It was sore to the touch by the veins. No real redness by the veins. Monday same thing but not as bad as Sunday. Tuesday, was a little sore but not so much in my calf where it originally started. barely any pain to the touch on my calf. My inner thigh is where I still feel the pain. Sensitive to the touch by the varicose vein. No real redness. Most pain just like I mentioned above is from sitting to getting up and walking around. Do you think the vayvanse broke off a blood clot and it is slowly making its way through my varicose veins back to my lungs and or heart?
Mon, 29 Jun 2015
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Pathologist and Microbiologist 's  Response
Hello, First of all please stop taking the Vyvanse. One of its side effects is muscle pain as you have described. It is a drug that should not be taken unless specifically prescribed by a physician. Regarding the worry about blood clots as you have expressed , blood clots in varicose veins rarely travel to the heart because varicose veins are superficial veins. The problem of a blood clot breaking and travelling upwards to the lung and heart which we call as pulmonary embolism in medical terms arises due to a blood clot or thrombus in the deep veins of the lower limb. One must remember that while varicose veins as such are not dangerous, deep leg vein clots called deep vein thrombosis in the leg is dangerous. Deep vein thrombosis can present as calf pain with an increase in size of the affected limb etc. This condition is investigated using tests such a Doppler test and D-Dimer test. Please get the following tests done- Complete blood count, creatinine kinase, Doppler test of the lower limb, CT pulmonary angiography . Some pulmonary emboli may be clinically silent , however some may cause sudden death. Since your cholesterol levels are high ,I presume that you are managing it under medical supervision. You may get a more detailed lipid profile assessment which includes LDL, HDL, apolipoproteins, hs CRP etc. However , the most important step is to exclude deep vein thrombosis in your case even though that is a rare possibility here because deep vein thrombosis usually occurs in people who have had prolonged bed rest, after surgery/trauma, certain cancers, certain rare inherited disorders which cause the blood to clot inappropriately etc. Best regards
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What Cause Elevated Level Of Cholesterol?

Hello, First of all please stop taking the Vyvanse. One of its side effects is muscle pain as you have described. It is a drug that should not be taken unless specifically prescribed by a physician. Regarding the worry about blood clots as you have expressed , blood clots in varicose veins rarely travel to the heart because varicose veins are superficial veins. The problem of a blood clot breaking and travelling upwards to the lung and heart which we call as pulmonary embolism in medical terms arises due to a blood clot or thrombus in the deep veins of the lower limb. One must remember that while varicose veins as such are not dangerous, deep leg vein clots called deep vein thrombosis in the leg is dangerous. Deep vein thrombosis can present as calf pain with an increase in size of the affected limb etc. This condition is investigated using tests such a Doppler test and D-Dimer test. Please get the following tests done- Complete blood count, creatinine kinase, Doppler test of the lower limb, CT pulmonary angiography . Some pulmonary emboli may be clinically silent , however some may cause sudden death. Since your cholesterol levels are high ,I presume that you are managing it under medical supervision. You may get a more detailed lipid profile assessment which includes LDL, HDL, apolipoproteins, hs CRP etc. However , the most important step is to exclude deep vein thrombosis in your case even though that is a rare possibility here because deep vein thrombosis usually occurs in people who have had prolonged bed rest, after surgery/trauma, certain cancers, certain rare inherited disorders which cause the blood to clot inappropriately etc. Best regards