My dtg started with essential tremors to her upper exts. et purplish-brown nails when age 12. She is now 19 et all is worse. We have been to x 4 different CMC et John Hopkins. Many neurologists, rheumoidologists, internal medical MD s, pediactricians. ANA always super high. Nobody can give us a dx. She is a nsy student, active, exercises, eats well, et thin statue. Tremendous amts of lab tests over years. Trembling increasing... been on several beta blockers, doesn t seem to help. Please help concern mother, had EMG , MRI brain, Echo, all neg. Thanks so much for your time, effort, et intelligence. Concerned et terrified mother, Barb