Hi, Penidure (also known as Benzathine Penicillin) is an antibiotic medication used to treat bacterial infections such as strep throat, syphilis, and diphtheria. It is generally considered safe and effective for most people, but like all medications, it can cause side effects. Some common side effects of Penidure may include: - Nausea or vomiting - Diarrhea - Stomach pain or discomfort - Headache - Dizziness - Allergic reactions (rash, itching, swelling, difficulty breathing) Less commonly, Penidure can cause more serious side effects, including: - Severe allergic reactions such as anaphylaxis - Stevens-Johnson Syndrome (a serious skin reaction) - Hemolytic anemia (a type of blood disorder) - Kidney damage - Neurological side effects such as seizures or confusion The symptoms of stiffness in the finger joints and itching in the mesh of the umbilical hernia surgery that you are experiencing could potentially be side effects of Penidure, although they are not common side effects. It is important to inform your doctor about any new or worsening symptoms you experience while taking this medication. Overall, the benefits of taking Penidure generally outweigh the potential risks of side effects, especially in cases where it is being used to treat serious bacterial infections. However, it is important to follow your doctor s instructions carefully and report any new or concerning symptoms to them. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Priyanka, General & Family Physician