Thanks for your query.
Progestins, in general, should be withheld during pregnancy. Progestins cross the placenta. Although many studies fail to demonstrate an increase in teratogenicity when progestins are given in the first trimester, the possibility that genital abnormalities may appear in male and female fetuses exposed to progestins during that period has been suggested by some studies. The low number of abnormalities reported include an increased risk of hypospadias
in male fetuses exposed to intrauterine progesterone
of the female fetus' external genitalia when exposed to ethisterone
. There is some controversy about the reliability of these reports.
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