Hi, Thanks for writing to us, I have gone through the provided history. Whether the drugs are right for her or not depends on how much improvement she has shown so far. She is currently on two antidepressants ( Zoloft and Remeron), two sleeping pills/sedatives ( Klonipin and Lunesta), one mood stabilizer (Lamictal) and an antipsychotic (Seroquel). Firstly, get her evaluated for the physical problems she has by a general physician and if necessary, get the required treatment and rule out depressive illness to be a cause of these problems (yes depressive illness can present with such complaints). Secondly, a second antidepressant is added only after the first antidepressant is optimally tried for sufficient duration. You have not mentioned those details hence i would not be able to comment on that. And in my opinion there is no need for two types of sedatives and taking it only at night would avoid the drowsiness she experiences. If these drugs have been used for a long duration then they should not be stopped abruptly, especially klonopin. It has dependent or addictive properties due to which it is prescribed only for a short duration. Also, Remeron has sedative properties. The benefits of this drug needs to be weighed against the sedative side effect. Kindly talk to her psychiatrist regarding this. It is better if a family member accompanies the patient to a psychiatrist because he/she can get more reliable history about the patient. Hope this helps, Dr A Rao