Hello dear I understand your concern Chronic constipation could be due to irritable bowel syndrome, sedentary lifestyle, enteropathy, inadequate fiber in diet as colonoscopy was normal. The more the bowel is not emptied the more difficult it becomes to evacuate as the liquid content of the stool is reabsorbed. The stool becomes hard and this hard stuff goes on accumulating in the gut produce symptoms. I would suggest to consult the gastroenterologist and undergo stool examination, ultrasound scan of abdomen,colonic transit studies, defecography. Following advice will help you: Glycerine enema for immediate relief Syrup Lactulose: can be taken up to 30 ml twice a day Tab bisacodyl at bedtime can useful Bulking agents like isabgol husk Lifestyle changes: Drink one spoon of honey in warm water daily in morning before the bowel movement. Eat high fiber diet. Every meal should have salads and fruits with skin. Drink 2-4 litre water daily Daily evening and morning walk for 30-45 minutes to regularize the bowel movement. Take more fruits and green leafy vegetables in the diet. Set Up regular time for the motion. Hope this may help you Contact HCM for further health query Best regards Dr. Sagar