Thank you for asking Healthcare majic. My name is Dr Ehsan Ullah & I have gone through your query. your main concern is regarding treatment of E-Coli. well, treatment of the E.coli infection depends on two key aspects A) Site of the infection B) Severity of infection In Addiotion to Medication, there is also Need of some Life style modifications in the form of keeping the -pateints well nourished (Avoid dehydration) - Supply of adequate Oxygen -Blood pressure support. Antibiotics take care of E. Coli infection well. Another aspect you mentioned here is her CF . by which if you mean Cystic fibrosis then Immediate attention and treatment to this E. Coli is essential since Cf is genetic disorder which already compromises the patient s Lungs, Sinus and growth . most commonly used drugs are Cephalosporins (e.g Cextriaxone) , a type of antibiotics in cases of E coli involvement of barin (Meningitis), Chest (Pneumonia), Gall Bladder (Cholycystitis , cholingitis) in addition Flouroquonolones (another group of antibiotics ) Can be used. Other Organs if involved need different type of antibiocs depending upon severity. Hope this may help you. Let me know if anything not clear. Thanks.